The United Nations General Assembly affirmed that Israel must give up its nuclear weapons in a 149-6 vote taken on Wednesday.
An earlier version of the text was approved in the UNGA's Fifth Committee in October with a 152-5 vote.
Ukraine had voted against Israel in the Fifth Committee, but this time around was absent from the proceedings after it had been criticized for standing against Israel.
Those who opposed the resolution were: Canada, Israel, Micronesia, Palau and the United States. Liberia, which had been absent from the vote in October, changed its position and opposed the text.
Another 26 countries, including India and many European states, abstained from the resolution which is part of an annual package of over 15 anti-Israel and pro-Palestinian texts the UNGA approves.
Israel is the only country subject to that many resolutions.