Most of the pictured children are from the northwestern Hama and Idlib provinces, both scenes of intense conflict in recent weeks.
Children hold up photos of popular Pokémon characters alongside backdrops depicting their horrific narratives.
Activists at the Revolutionary Forces of Syria Media Office and others like Moustafa Jano, a Syrian refugee living in Sweden, also created similar images.
Since its short debut, Pokémon GO has taken the number one spot on the iTunes app store in over 20 countries and has more than doubled the value of its parent company Nintendo.